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Depending on the reason it's being prescribed, it can be anywhere from daily to every three days to once a month

doi: 10.3389/fphar.2014.00280 Received 01 October 2014 Accepted 02 December 2014 Published 18 December 2014 Volume 5 - 2014 Edited by Dominique Massotte, Institut des Neurosciences Cellulaires et Intgratives, France Reviewed by Chris Bailey, University of Bath, UK

Optimal results generally require 6 or more months of consistent use

Data also points to its potential influence on other fibroblast populations within the dermis, particularly those deemed responsible for the production and renewal of the extracellular matrix

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Some may notice changes sooner, while others may see more gradual effects over time