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We further demonstrated that an increase in urinary GSH concentrations during the formation of TLS is a common phenomenon in both mice and humans and proposed the utility of urinary GSH as a biomarker to detect TLS in the kidney

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While the BBB serves as a barrier to restrict the passage of molecules, the integrity and function of the BBB can be compromised by disease states, disease-caused inflammation, and immune responses in the brain [1, 3, 9], or even systemic infection and inflammation [10] resulting in BBB disruption and greater BBB penetration [11]