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Normal expression of GPx1, however, is associated overwhelmingly with protection, in that normal expression of GPx1 results in less severe consequences than conditions with GPx1 deficiency in many diseases and, in diseases where ROS-mediated damage plays a crucial role in the pathogenesis, excess GPx1 is beneficial

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STAT3-RXR-Nrf2 activates systemic redox and energy homeostasis upon steep decline in pO 2 gradient
