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A complicating factor in clinical trials has been the significant inter-individual variability in susceptibility to APAP toxicity 14

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It has been proposed that omics technologies, including proteomics, genomics, lipidomics, epigenomics, metabolomics, analysis of the microbiome, modern imaging methods, and physiological monitoring approaches, may once again play an important role, as they have already proven effective in fostering the implementation of precision medicine in daily practice ( The Continuum Concept, one of the most fundamental principles of physiology, biology, and disease, explains the status of an individual from optimal health to a hidden imbalance, progressing to severe dysfunction, ultimately leading to disease ( 2.2 Health and the power of lifestyle The desire for a happy and long life (with as few years lived with disability as possibleespecially at the end of one's lifespan) has been a fundamental human aspiration and traces back to the beginning of humankind (Figure 2) reported for the first time that the human lifespan can be extended by making lifestyle modifications ( Figure 2 Today, the lifestyle medicine concept is a concrete, evidence-based, and comprehensive approach to preventing, treating, and even reversing various diseases by implementing health-promoting behaviors and replacing poor/unhealthy ones that are disadvantageous to health in daily routines

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