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Conflict of interest statement EOL, BJ, GZ, PM, AMcC, MTG, TT, TWR, GBV, MEK, CM and SB are current and former MRL employees and were or are employees of Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA and shareholders in Merck & Co., Inc., Kenilworth, NJ, USA at the time of their contributions