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Deiodinase 1 mRNA and protein expression and activity are downregulated as MASH progresses to cause intrahepatic hypothyroidism

Khera R, Murad MH, Chandar AK, Dulai PS, Wang Z, Prokop LJ, Loomba R, Camilleri M, Singh S (2016) Association of pharmacological treatments for obesity with weight loss and adverse events: a systematic review and Meta-analysis

[DOI] [PubMed] [Google Scholar] 264.Yee J

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Regarding adrenal steroidogenesis inhibitors, ketoconazole exerts cholesterol-lowering effects by inhibiting adrenal steroid synthesis and hepatic cholesterol production, historically serving as a therapeutic option for familial hypercholesterolemia before the advent of statins [292, 293]

However, despite the many advances in CAD treatment, the disease is invariably associated with many limitations, most significantly the comorbid conditions that complicate treatment protocols and patients quality of life