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Description
Targeting M2phenotypic TAMs reduces the polarization of macrophages toward the M2 phenotype and raises the amount of M1-TAMs, which in turn strengthens the anti-tumor immune microenvironment (38)
Neh1, as a CNC-bZIP domain, permits Nrf2 to heterodimerize with the small musculoaponeurotic fibrosarcoma (Maf) protein and to form a nuclear complex with the UbcM2 ubiquitin-conjugating enzyme
Duration varies between individuals
With these advancements, we believe that RR will achieve personalised applications in preventive medicine in the near future
doi: 10.2165/00023210-200923020-00001
Kelley, E
