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Molecular Psychiatry, 24(9), 12481257

2022, 56 (9), 5453 5475, DOI: 10.1111/ejn.15372Google Scholar30The role of extracellular matrix alterations in mediating astrocyte damage and pericyte dysfunction in Alzheimer's disease: A comprehensive reviewAnwar, Mai M

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J., Kennedy, P

Although the presence of ferroptosis was first demonstrated in cancer, given the increasing number of associated studies, ferroptosis has been shown to fulfill an important role within the nervous system (11,2630), and common neurological disorders, including ischemic stroke (31), Alzheimer's disease (32) and Parkinson's disease (33), have been found to be closely associated with ferroptosis, the latter two being common neurodegenerative disorders wherein the molecular mechanism is mainly concerned with an aggregation of iron in the hippocampal region of the brain or in dense areas of the substantia nigra, and these responses have been shown to be inhibited by the ferroptosis inhibitor, ferrostatin-1 (Fer-1) (3436)

It is that you activate receptors on different neuronal populations that independently regulate appetite, metabolism, and energy balance