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A NAM-only project and an Australia-first clinical trial are not the same decision

It is important to note that curcumin exhibits a biphasic dose-response relationship: lower doses activate protective pathwaysincluding increased total glutathione (GSx) and GST activitywhile higher doses deplete GSH, reduce related metabolites (e.g., taurine, homocysteine), and may induce pro-oxidant effects or cellular toxicity (Scharstuhl et al., 2009)

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The reason is because after the 2 nd round, there is often additional improvement noted

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Tumor cells deficient in mitophagy exhibit heightened susceptibility to ferroptosis inducers due to the loss of this protective mechanism (46)