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Subacute and chronic injuries predominantly feature demyelination of the nervous system and megaloblastic anemia, with up to 96% of patients experiencing neurological damage ( Spinal Cord Lesions: Symptoms include gait instability, sensory deficits, and motor weakness, often progressing to paraplegia in severe cases ( 6.4 Auxiliary examinations 6.4.1 Imaging characteristics MRI findings often reveal T2 hyperintensities in the posterior columns of the spinal cord and subcortical white matter ( 6.4.2 Laboratory and neurophysiological examinations Decreased Vit B12 levels and elevated Hcy and MMA are hallmark findings in NO-induced neuropathy ( 6.5 Diagnosis and differential diagnosis Based on clinical experience, the diagnostic criteria for neurological damage due to long-term NO inhalation include the following: A history of NO exposure, particularly frequent short-term inhalations

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