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Description
The signature HLH domain normally mediates protein dimerization and is required for DNA binding
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2018) now opens the door for limiting TMAO exposure by non-lethal drugging of the gut microbiome (Brown and Hazen 2017) to reduce TMAO levels and prevent, slow, or reverse fibrosis
This phenomenon involves conformational changes in the enzyme structure, particularly the opening of a lid domain that exposes the active site and creates a hydrophobic binding surface for lipid substrates
