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10.7150/ijbs.49535 95 Reyes-FerminL

However, when serine is available, neither restricting exogenous glycine intake nor depleting the endogenous glycine cleavage system can inhibit the proliferation of cancer cells, indicating that nucleotide synthesis and cancer cell growth are supported by serine rather than glycine consumption [171]

Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse

It is possible that the decreased dietary intake may activate regulatory mechanisms that increase synthesis and/or absorption and decrease excretion of L-carnitine [65,70,71]

It is interesting that aside from caffeine metabolism, the major enriched pathways are related to amino acid metabolism, as recent reports have found alterations in amino acid metabolism in other neurodevelopmental disorders, notably autism (Smith et al., 2019)

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