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Keywords: obesity, therapeutics, nicotinamide N-methyltransferase, inhibitors, weight loss Graphical abstract 1

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The Clinical Evidence: What Trials Actually Showed Evaluating AOD-9604 before-and-after outcomes requires separating animal data from human data

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Drug Interactions: Certain medications, like metformin and stomach acid reducers (PPIs), can interfere with B12 absorption from food, which may increase the need for injections

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