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Owing to the glycolytic nature of HSCs, compared to the hematopoietic progenitors and mature hematopoietic cells, they have reduced mitochondrial respiratory capacity, turnover rate, and mitochondrial activity but a high mitochondrial mass (10, 11)

The less tyrosinase is active, the less melanin is produced

While both GSH and GABA have been implicated in various neurological disorders, the current study provides valuable insights into the specific context of ASD and highlights the need for further research to explore other neurochemical alterations that may contribute to the pathophysiology of this complex disorder

The interaction between GDAP1 and MFN2 [37] and their shared location in the OMM underscore the fundamental role of the mitochondrial membranes in maintaining the health of peripheral nerves [38] and would explain how digenic inheritance contributes to phenotypic variability in CMT

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