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DOPAL Neurotoxicity Amongst the several determinants of the degeneration of SNpc DA neurons, the possible endotoxicity associated to dopamine dyshomeostasis is an important factor to consider

At the lowest concentration treatment, DEHA significantly enhanced the expression of the thyroid-stimulating hormone beta subunit gene ( tsh ), while significantly reducing the expression of dio2 at higher concentrations [171]

Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR)

Ngo V, Brickenden A, Liu H, Yeung C, Choy WY, Duennwald ML

Another CYP4F family member, identified as CYP4F2, has also been shown to exhibit LTB 4 -hydroxylating activity

Among the metals for which this mechanism has been demonstrated are: zinc [157], cadmium [149,158,159], mercury [160,161], manganese [159,161,162,163], cobalt [164], nickel [165]