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Accurate characterization of fatigue in patients taking GLP-1 receptor agonists requires careful clinical assessment to distinguish true fatigue from related symptoms and to identify potentially serious underlying causes

One commonly cited example is insulin, a naturally occurring peptide with a well-understood structure and function in glucose regulation, studied extensively in biochemical research

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It was originally developed as a diagnostic tool to assess pituitary GH secretory capacity and was later FDA-approved for the treatment of growth hormone deficiency in children