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Due to its strong scavenging activity of free radicals, lycopene has a powerful ability to protect the kidney, liver, and nervous system from oxidative stress (Zhang et al

4c,d), plasma insulin at min 30 of the IPGTT was 20% higher while blood glucose was significantly lower in N5-WT compared with N5-Tr mice, strongly suggesting in vivo GSIS is improved in N5-WT vs N5-Tr male mice

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Therefore, activation of TRPA1 in neurons by oxidative stress such as H 2 O 2 was reported (Materazzi et al., 2012

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All samples were analyzed in triplicate, and the 16 S rRNA gene was used as an endogenous control, as described in our previous publication