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While regular physical activity confers neuroprotection through multiple pathways [109], emerging evidence indicates that sedentary behavior independently contributes to PD risk, possibly via chronic systemic inflammation and reduced cerebral perfusion [110, 111, 112, 113]

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VIP Vasoactive Intestinal Peptide is a neuropeptide with regulatory effects across multiple systems
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Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis