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In a multicenter retrospective study of over 500 patients undergoing treatment with either IV or oral NAC or both for acetaminophen poisoning, NAC was associated with nausea and vomiting rates of 7.2 and 6.5%, respectively, in the IV group compared with 20 and 13.1% in the oral cohort [83]

It would be highly desirable to conduct a trial studying absorption of glutathione from the human orobuccal mucosa comparing administration in the form of a lozenge versus an HPC film which theoretically offers more rapid absorption over a larger surface area

In addition, ascorbates labeled for positron emission tomography (PET), namely [1- 11 C]DHA and [1- 11 C]VitC, have recently been synthesized and studied in ROS-producing immune cells in vitro 21

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As for the disadvantages, Zinc Oxide is also not cosmetically elegant

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