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This reflects a change in focus from diagnosis based on symptoms to diagnosis based on pathophysiology, in this case hypocretin (orexin) deficiency status

In FM patients, stimulation of target areas such as the primary motor cortex (M1) [59], dorsolateral prefrontal cortex (DLPFC) [62, 68] and operculo insular cortex (OIC) [66, 67] improves fatigue [69], quality of life (QoL) [69], pain catastrophizing and pain-related disability [68]

Potential Health Risks Associated with Bathing in A Tropical Bay in Grenada, West Indies

Using machine learning to predict extreme events in complex systems

Br J Pharmacol 2000

Mechanisms regulating intestinal barrier integrity and its pathological implications
