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The DMPD assay is particularly well-suited for assessing hydrophilic antioxidants but is less responsive to hydrophobic bioactive compounds, a limitation not shared by other assays

It has been reported that biotic and abiotic stress often induces the overproduction of reactive oxygen species (ROS) such as the superoxide radical (O 2 ) and hydrogen peroxide (H 2 O 2 ) 14

Methotrexate, a chemotherapy drug, works by inhibiting the production of methyl folate, thus limiting methionine and DNA synthesis for cell growth

In my clinic, nerve conduction studies in patients with such symptoms revealed nothing abnormal for example, there was no evidence of peripheral neuritis

Healthcare providers should maintain open communication about all treatments patients are using and provide evidence-based guidance prioritizing interventions with established safety and efficacy profiles

10.1038/s41386-019-0486-5 11