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8 The body requires a delicate balance between production and detoxification/transport of harmful reactive species and protein adducts, and when these defenses are overwhelmed at hepatotoxic doses of APAP, the glucoronidation and sulfonation pathways become saturated, pushing the majority of APAP to be metabolized to NAPQI by the CYP 2E1 pathway and resulting in GSH depletion and build-up of toxic NAPQI

[DOI] [PubMed] [Google Scholar] 95.Cummings R.T., Walsh C.T

13 The de novo synthesis of GSH uses glutamine, cysteine, and glycine, and takes place in two steps, both requiring ATP

This is exactly why liposomal delivery exists

Yes, small pilot studies have investigated intra-articular injection for knee osteoarthritis, with subjective pain improvement reported but no controlled trials completed

Glutathione also acts as an antioxidant that acts to prevent oxidative stress in most cells and help to trap free radicals that can damage DNA and RNA, Milk Thistle Extract and Alpha Lipoic Acid are included to enhance Glutathione's liver supporting properties