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They all involve the progressive loss of neurons and neural connections

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"Nicotinamide N-methyltransferase (NNMT): a novel therapeutic target for metabolic syndrome." Frontiers in Pharmacology

If these conservative measures fail, the next traditional step is often a corticosteroid injection
[DOI] [PMC free article] [PubMed] [Google Scholar] [88].Diamond B, Bloom O, Al Abed Y