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Abstract Background: Vitamin B12 deficiency is a widespread condition, particularly among elderly individuals, patients with malabsorption syndromes, and those following plant-based diets

It works by blocking the NNMT enzyme in fat cells and other tissues, which prevents the conversion of nicotinamide to 1-methylnicotinamide

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Unlike full-length hGH, AOD-9604 appears in preclinical studies to act without significant activation of the growth hormone receptor pathway or substantial increases in circulating IGF-1

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Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B12 deficiency: randomised placebo controlled trial