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[37,38] Clinically manifest or latent persons with disease are at increased risk for developing hepatocellular carcinoma (HCC), typically after age 54

This is felt to be due to the detoxification effect of B12 in patients who have methylation issues

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[DOI] [PubMed] [Google Scholar] 7.Pires A., Fortuna A., Alves G., Falco A

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Xu and co-workers (109) showed that hypothalamic expression of NPY and AgRP is tightly regulated across the estrus cycle, with the lowest levels during estrus, which coincides with the E2 peak and feeding nadir in wild-type mice