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In this context, activation-induced mitochondrial reactive oxygen species (mROS) production caused a rapid, extensive DNA damage response and consequently PARP1 activation with associated NAD + consumption

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[PubMed] [Google Scholar] 96.Tiercy J.M., Claas F

As GSTP1 knockdown significantly increased cisplatin and carboplatin chemosensitivity in A2780 cells, we further investigated whether GSTP1 knockdown in the related platinum-resistant A2780DPP cell line (Behrens et al, 1987) could re-sensitise these drug-resistant cells to platinum-based chemotherapy

This neurological support extends to protecting against age-related cognitive changes, as research shows that glutathione depletion is associated with declining mental acuity