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The cobalamin is transported into the cytosol through the LMBD1 protein, possibly drawn through the lysosomal transporter by interaction of the cytosol face of LMBD1 with the MMACHC protein

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This compound downregulates the expression of the anti-apoptotic Bcl-2 protein while increasing Bax and caspase-3 levels [174]

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KRAS G12C (41%), KRAS G12V (22%), KRAS G12D (12%), and KRAS G12A (9.3%) represent the most commonly observed mutations in KRAS within lung cancers (7, 27)

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