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Cytokine involvement in the pathogenesis of the disease, specifically IL-8 and IL-6 [24], has been extensively studied for its role in tissue damage and subsequent disease progression [31]

HIF-1 promotes a metabolic shift in hypoxia by inducing PDK1, which inhibits pyruvate entry into the TCA cycle and redirects glucose metabolism to glycolysis to sustain ATP and reduce ROS (Kim et al., 2006

The presence of FAD-binding region and transmembrane hemes enable NOXs to act as an electron-transportation chain that transfers two electrons from cytosolic NADPH to extracellular O 2 , resulting in the generation of O 2

Thng hiu: Angel's Liquid Dung tch: 50ml Xut x: Hn Quc S dng vo bui ti sau cc bc nc hoa hng v serum

Acta Physiol Scand 161, 379384

The fermentation broth was centrifuged at 6250 rcf for 15 min at 4C to obtain CFS