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Ultimately, both JNK and Bax translocation contributes to release of mitochondrial proteins into the cytosol and then their translocation to the nucleus as detailed below, to ultimately result in hepatocyte necrotic cell death (Fig

doi: 10.1158/0008-5472.CAN-07-5875

2 Next-generation sequencing studies using primary cells from AML patients have established that FLT3- ITD mutations occur relatively late in leukemogenesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Huang C., Wu J.J., Chen D.J., Jin J., Wu Y., Chen Z

Detoxification: Glutathione aids in the detoxification process by binding to toxins and facilitating their removal from the body

Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcgRIII an antibody-dependent cellular toxicity