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48 ADMA-induced endothelial dysfunction leads to proteinuria, a sign of glomerular damage associated, in turn, with proinflammatory cytokines secretion, which increases the production of ROS, worsening renal damage

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This results in visible skin whitening and a bright, glowing complexion

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*Correspondence: Romualdo Sciorio, [email protected] ORCID: Romualdo Sciorio, orcid.org/0000-0002-7698-8823 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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