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For instance, in the brain, it has been described that neurons operate in a strong physical and metabolic association with astrocytes and glial cells, and the dysregulation of this cooperation contributes to the development of brain disease ( Unlike other types, human brain organoids are usually generated only from human pluripotent stem cells (both hESCs and hiPSCs), mainly due to the low regenerative capacity of the adult human brain (Tang et al., 2022)

This, in turn, results in the incorporation of glycated proteins inside thrombi (173)

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Research (154) has shown that silencing pannexin-1 can promote the expression of the intracellular antioxidant enzyme HO-1 and inhibit ferroptosis through the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway, thereby reducing ischemia-reperfusion injury in the kidneys