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Furthermore, curcumins role in reducing AMD progression has been supported by studies indicating a reduced risk of nonexudative and advanced AMD with its use [111]

The most commonly noted clinical feature at initial presentation was progressive cardiomyopathy, which occurred in 12 of the 20 patients in the cohort

Coleman and Blass (108) first identified the presence of lactic acidosis in a small set of patients in 1985, with Lombard (109) later proposing that ASD may be at least partially due to abnormal neuronal oxidative phosphorylation

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