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These three remove hardness, chlorine, and particulate matter, respectively

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This is significant as the gut microbiota has been implicated in the pathogenesis of metabolic diseases

It is noteworthy that these six new small-molecule peptidic metabolites were similarly detected in the urine, bile, fecal, and plasma samples

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The association of TNX deficiency with EDS is exciting because it simultaneously establishes the first clinically relevant function for any of the tenascins and immediately broadens the search for EDS candidate genes beyond the collagens and their modifying enzymes