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GPX2 protein concentrations are highest at the bottom of the crypt and then gradually descend to the top of the colonic crypt or small intestinal villi (Florian et al., 2001)

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Target genes for each condition were first retrieved from the GeneCards database using disease-specific queries, followed by identification of their intersection as RA-FMS comorbidity targets

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A minimal reaction set that captures this entry chemistry is: These reactions matter mechanistically because they couple NO x uptake to apoplastic acidification and to nitrite pools that can feed downstream reactive nitrogen species formation, especially under co-occurring A key damage-amplifying route arises when NO-derived intermediates meet superoxide generated by stress-activated oxidases or organellar leakage, forming peroxynitrite: Peroxynitrite chemistry is central because it provides a direct molecular explanation for the formation of nitroproteomes in plants under stress and for why NO x effects become stronger in mixtures that elevate ROS (Mata-Prez et al., 2016)