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Thus, it was proposed that polyhydroxycurcuminoids might be better candidates than curcumin as a dietary supplement in the prevention and therapy of AD (Hoppe et al., 2011)

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10.1186/1423-0127-17-S1-S23 J

1.1 Pathophysiology of tight junction proteins Tight junction (TJ) proteins connect adjacent epithelial cells on their apical side and therefore are critical for controlling paracellular permeability by selectively regulating the flow of ions, solutes, and small molecules across the epithelium