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Key pro-inflammatory cytokines, including TNF-, IL-1, IL-6, and IL-17, are significantly upregulated in the degenerative nucleus pulposus (NP) (Risbud and Shapiro, 2014)

FIGURE 3 Together, these findings suggest that HA + GSH-C4 induces a transient, reversible cytokine activation with repair-associated Th1/Th17 features, with IFN- and IL-12p70 persisting even after crossover to HA alone

J.LuY.WangH.et al

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[DOI] [PubMed] [Google Scholar] 211.Kataria N., Yadav P., Kumar R., Kumar N., Singh M., Kant R., Kalyani V

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