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This is due to uncoupling of electrons during their transfer from NADPH cytochrome P450 reductase to cytochrome P450, or from cytochrome P450 to its substrates,2 as was shown to occur for ethanol3 and benzo(a)pyrene4 metabolisms, among many others

Oxidative stress: excessive accumulation of ROS In a healthy condition, the production of ROS is balanced by various antioxidant systems [2,33]

A.BernatN.OdesserT.InbarD.KupchikY

Emotional and physical stress: Performance anxiety elevates cortisol, which increases systemic inflammation

Similarly, exosome-released miR-142-3p from hepatocellular carcinoma (HCC) cells targets SLC3A2 expression, inducing ferroptosis in M1 macrophages

BMC Pharmacol Toxicol