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Our study is first to demonstrate novel molecular mechanisms involved in the sensitization of PTC cells to ferroptosis inducer- we show that RSL3, a potent direct GPX4 inhibitor, effectively reduces the viability of thyroid cancer lines with various mutational backgrounds compared to HThF control cell line in a dose-dependent manner

NAD+ levels rise (a key molecule in energy production) Mitochondrial efficiency improves Fatty acid oxidation increases Adipogenesis (fat cell development) decreases In animal studies, 5-Amino-1MQ: Reduced body fat by 3040% Increased lean muscle mass Improved insulin sensitivity and glucose regulation Additionally, it helps preserve metabolic rate during calorie restrictiona major factor in long-term fat loss success

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doi: 10.2337/dci23-0100

[DOI] [Google Scholar] Korany, A