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Key immune-related ferroptosis gene signatures and their clinical relevance are listed in Table 3
In a study on acute endotoxininduced lung injury, treatment with iNOS inhibitors was reported to suppress the production of pro-inflammatory cytokines
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Moreover, the serum concentration of IL-1 and IL-6 correlated inversely with serum selenium [77]
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Taken together, these results indicate that increased expression of xCT/Slc7a11 through Nrf2 hyperactivation in Keap1 mutant cells is necessary for the increased glutamine dependency and sensitivity to glutaminase inhibitors
