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Al-Mudhaffer RH, Ahjel SW, Hassan SM, Mahmood AA, Hadi NR

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Figure 4 Inhibitory Effects on Key Enzymes in l-2HG Pathway The finding that at higher iron concentrations less glutarate and more l-2HG accumulated, while the combined concentration of glutarate plus l-2HG was highest at the lowest iron concentration indicated bottlenecks