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While its safety profile was consistently favorable, the largest Phase IIb trial failed to show statistical significance for weight loss, and commercial development was halted in 2007.[2] Despite this, interest in AOD-9604 has continued in the compounding pharmacy and integrative medicine space, particularly given its safety data, its lack of IGF-1 stimulation, and emerging research around joint health

Acute side effects resulting from radiotherapy include erythema and epilation in the treated area, which start from the second week of treatment

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This allows for a ratiometric and concentration-independent determination of the probes dithiol disulfide state by fluorescence measurements

We thank Christine Heiner (Department of Surgery, University of Pittsburgh) for her critical reading of the manuscript

Promotion of color-changing luminescent hydrogels from thermo to electrical responsiveness toward biomimetic skin applications