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Mechanism Of Action KPV modulates inflammation by downregulating pro-inflammatory cytokines such as TNF- and IL-1

Impaired homocysteine metabolism-mediated moderate hyperhomocysteinemia (caused by folate deficiency, vitamin B 6 deficiency, or by methionine excess) might thus have primarily pro-oxidant effects resulting from an altered extra- and intracellular redox potential that can affect essential vascular functions

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Late-stage treatments : Focus on combating neuroinflammation and extensive neuronal loss

For further studies, we utilised Gpx4 flox/wt ;Villin-Cre +/ ( Gpx4 +/IEC ) mice 27,28 , which specifically deleted one Gpx4 allele in the intestinal epithelium and resulted in a ~50% reduction of mRNA and protein levels in small and large intestinal IECs (Supplementary Fig