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160 The P2X7 receptors are ligand-gated ion channels and can be opened by binding of extracellular ATP, which increases Na + and Ca2 + influx and promote K + efflux through coordinating with the K + channel, leading to the activation of NLRP3 inflammasome

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doi: 10.1255/ejms.820

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doi: 10.1016/j.molimm.2018.05.009 232 Sanchez-JimenezPElizalde-HorcadaMSanz-GarciaAGranero-CremadesIDe ToledoMPulidoPet al

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