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Description
swing phase

Rh-2025u effectively disrupts the downstream signaling of this ternary complex, thus inhibiting the migration process of prostate CAFs (Di Donato et al., 2021a)

Unlike many peptides that act on a narrow range of biological targets, BPC-157 is studied for its multisystem signaling profile
The main reason is receptor desensitization : continuous stimulation of the same receptor makes cells less responsive over time, so a planned off period lets the receptor resensitize
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The first human safety study on health volunteers was conducted in 2002 and a phase 2 double blind, randomized clinical trial (small and not sufficient for US phase 2 purposes) was conducted in 2005 with BPC-157 enemas for ulcerative colitis, with some promising effects (see research name PL 14736 to find the references)
