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Synthesis, anticancer, and computational studies of 1, 3,4-oxadiazole-purine derivatives

The model construction and simulations were carried out with COPASI, which also performs MCA and calculates the flux control coefficients from the elasticity coefficients ( An ordered reversible ter-bi Michaelis-Menten equation (Equation 1) was used for PDH and 2OGDH kinetics, where A = Pyr or 2-oxo, B= CoA, C= NAD + , P= AcCoA or SCoA and Q= NADH

doi: 10.1073/pnas.91.22.10625

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