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2011;15:195797 [cited 2018 Jun 21]

Understanding the structure and function of ZIP transporters may offer valuable insights for developing new therapeutic strategies targeting zinc transporters to treat various human diseases

The inhibition of CSE or CBS, two endogenous H 2 S-producing enzymes, notably abolished the upregulated expressions of EMT marker proteins and p38 MAPK induced by radiation, indicating that H 2 S/CSE promoted EMT and p38 MAPK signaling pathways in HCC

Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone HSC70

Specific binding can be exhibited, e.g., by a low affinity targeting agent having a Kd of at least about 10 "4 M

91 Mitochondrial permeability transition pore (mPTP) The mPTP, a nonselective channel in the mitochondrial inner membrane, allows the passage of molecules up to 1.5 kDa in size
