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The PI3K/AKT pathway is an important regulator of cell cycle progression

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Tau is a phosphoprotein mainly localized in the axon of neurons for the stabilization of MTs

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Although the overall evidence suggests that at least a subset of patients with ME/CFS exhibit reduced cortisol output, some cohorts show only modest reductions, preserved cortisol output, or context-dependent abnormalities rather than stable hypocortisolism, indicating that HPA-axis dysfunction in ME/CFS is likely heterogeneous and multifactorial rather than a specific or uniform neuroendocrine abnormality (Tomas et al., 2013