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Perturbation of insulin-receptor interactions by intramolecular hormone cross-linking

Recently, agents that abrogate radiation-induced cell cycle checkpoints, such as Wee1 and Chk1 inhibitors, have been shown to radiosensitize tumor cells and are currently in clinical development in combination with chemotherapy, with clinical trials planned in combination with radiation

Handle under appropriate laboratory conditions and avoid repeated freezethaw cycles of the reconstituted solution

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A third method involves the stereotactic injection into the brain parenchyma of endothelin-1, a potent vasoconstrictor peptide