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(34221552) [2] It may increase irritability, so its suboptimal for patients with a history of agitation

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This binding activates the transcription of genes encoding antioxidant enzymes, detoxification enzymes, heat shock proteins, and apoptosis regulators, such as NAD(P)H:quinone oxidoreductase 1 (NQO1), HO-1, and glutamatecysteine ligase

Meyron-Holtz EG, Ghosh MC, Rouault TA

doi: 10.1152/ajplung.00300.2011

However, model advancements in recent years have improved the accuracy and efficiency of simulations