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30, 60, and 100 mg/kg) for 28 days showed exacerbated myocardial fibrosis through increased expression of collagen I, -SMA, and TGF- [114]

This latest approval of Roxybond fulfills an unmet need for an IR (immediate-release) opioid with abuse-deterrent technology that may reduce misuse and abuse while providing pain relief to medically appropriate patients when used as indicated, Paul Howe, chief commercial officer of Protega, said in a statement

444 IPC treatment effectively triggers the production and release of various endogenous ligands, including adenosine, 445 bradykinin, 446,447 opioids, 448 norepinephrine, 449 and acetylcholine